South Carolina Midlands Vacation Packages 2026 from $375

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Your South Carolina Midlands Vacation

Whether you're heading to South Carolina Midlands for its rich history, spectacular views or something else entirely, this destination is one you won't forget in a hurry. Create your ultimate break with one of our South Carolina Midlands vacation packages. With so much to see and do on a trip to South Carolina Midlands, it can be difficult to know where to start. Kick off your travels in Columbia at Riverbanks Zoo and Garden and Williams Brice Stadium — two popular attractions here. Another city worthy of a spot on your itinerary is Florence. Don't miss Magnolia Mall and Mcleod Regional Medical Center. Expedia has flights, hotels, car rentals and more to help you create your very own customized South Carolina Midlands vacation today.

The Latest South Carolina Midlands vacation packages

Price found within the past 48 hours. Click for updated prices.

Westgate Myrtle Beach Oceanfront Resort

Save 100% on your flight

$375

per person

Dec 11 - Dec 15

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Myrtle Beach (MYR)

8.6/10 Excellent! (1,456 reviews)

Marina Inn At Grande Dunes

$694

per person

Dec 19 - Dec 24

found 23 hours ago

Roundtrip non-stop flight included

Boston (BOS) to Myrtle Beach (MYR)

9.4/10 Exceptional! (1,853 reviews)

The Westin Charlotte

Uptown Charlotte

$878

per person

Dec 14 - Dec 18

found 13 hours ago

Roundtrip non-stop flight included

Boston (BOS) to Charlotte (CLT)

9.2/10 Wonderful! (1,014 reviews)

Sands Beach Club

$723

per person

Nov 12 - Nov 19

found 16 hours ago

Roundtrip non-stop flight included

Boston (BOS) to Myrtle Beach (MYR)

8.8/10 Excellent! (141 reviews)

The reason why I give my stay a one star because I had to move out of our condo on our last night of my trip. The reason the receptionist gave me was that the owner was coming to stay for that week. Unfortunately whenever the owner decides they want to stay the day you have booked the condo you will have to move into another condo. My family & I had to pack all of our stuff and move 2 doors down. This was very unprofessional & unacceptable!!! Someone came into our room while we were sleeping because the chair we had at the door was moved out of position. That’s very unsafe! No apology was given! No nothing! I will not be staying here again.

Reviewed on Oct 6, 2026

Charlotte Marriott City Center

Uptown Charlotte

$629

per person

Dec 18 - Dec 21

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Charlotte (CLT)

8.8/10 Excellent! (1,005 reviews)

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Where to stay in South Carolina Midlands

Find the best South Carolina Midlands areas and neighborhoods for the activities you enjoy most. Learn more about South Carolina Midlands

A large church with a tall bell tower and a cross on top.

Downtown Columbia

2 out of top 10 points of interest in this area

A magnet for visitors to the southeast, this compact city is a favorite for its charm, cuisine, historic neighborhoods, world-class museums and pretty green spaces.

A cityscape with a mix of modern and historic buildings, a large parking lot, and a clear sky.

The Vista

The Vista is popular for its abundant dining options, and if you're looking for more to see and do, you might think about a trip to Colonial Life Arena or Koger Center for the Arts.

A cityscape with prominent government buildings, including a large white structure with columns and a dome, surrounded by smaller buildings and a mix of green spaces and urban development.

Rosewood

If you're looking for some top things to see and do in Rosewood and surrounding area, you can visit South Carolina Military Museum and South Carolina State Fairgrounds.

A cityscape with a prominent historic building surrounded by modern skyscrapers.

Seven Oaks

Seven Oaks is noteworthy for its coffeehouses, and you can make a stop at top attractions like Saluda Shoals Park and Three Rivers Greenway.

A river surrounded by dense green foliage and white flowers.

Tega Cay

Discover a picturesque peninsula with a 27-hole golf course, croquet court, lighted tennis and pickleball courts, walking trails, and 13 city-owned parks. Enjoy the hilly, densely forested terrain and abundant wildlife.

Stay near popular South Carolina Midlands attractions

A cityscape at dusk with illuminated buildings, a prominent dome structure, and a well-lit street.

University of South Carolina

9.0/10 (2,467 reviews)

Walk around the campus of University of South Carolina, a top university in Columbia. Experience the area's acclaimed theater scene or attend a sporting event.

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A large sign for 'Fury 325' with a roller coaster in the background.

Carowinds Theme Park

8.8/10 (962 reviews)

Choose from 13 roller coasters, chase your friends in a bumper car, enjoy the water slides and beaches of Boomerang Bay, and walk with dinosaurs.

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A pond with flamingos standing in the water.

Riverbanks Zoo and Garden

8.8/10 (1,195 reviews)

Why not meet the animals who call Riverbanks Zoo and Garden home during your trip to Columbia? You can attend a sporting event while in the area.

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A swampy forest with tall trees and a calm water body reflecting the sky.

Congaree National Park

8.4/10 (365 reviews)

While protecting southern hardwood forest for the enjoyment of future generations, this park also offers hiking, canoeing and interesting ranger-led activities.

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Darlington Raceway

8.2/10 (151 reviews)

Catch an event at Darlington Raceway during your trip to Darlington. While in this trendy area, you can savor the top-notch restaurants.

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Colonial Life Arena

8.8/10 (1,029 reviews)

Catch an event at Colonial Life Arena during your trip to Columbia. Experience the area's acclaimed theater scene or attend a sporting event.

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Williams Brice Stadium

8.8/10 (938 reviews)

Catch an event at Williams Brice Stadium during your trip to Columbia. You can attend a sporting event while in the area.

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South Carolina Midlands Hotel Deals

Hilton Garden Inn Columbia/Harbison

434 Columbiana Dr Columbia SC

Fully refundableReserve now, pay when you stay

$85 nightly

$96 total

Oct 18 - Oct 19

Total with taxes and fees

8.8/10 Excellent! (2,288 reviews)

"Beautiful property! Friendly professional staff! Close parking! Great place to stay!"

Reviewed on Oct 9, 2026

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

7333 Garners Ferry Rd Columbia SC

Fully refundableReserve now, pay when you stay

$102 nightly

$114 total

Oct 12 - Oct 13

Total with taxes and fees

Sleep Inn Columbia

1901 Rockland Rd Columbia SC

Fully refundable

$84 nightly

$91 total

Oct 31 - Nov 1

Total with taxes and fees

8.2/10 Very Good! (1,203 reviews)

"Room is smelly. I killed a roach inside my room. Breakfast leaves much to be desired. I have reported many times about the poor waffle maker and the fact that the completely made waffle gets stuck onto the waffle maker and sometimes gets completely destroyed trying to pull it off the maker but nothing ..."

Reviewed on Oct 8, 2026

See all 3,388 properties in South Carolina Midlands

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.