South Carolina Midlands Vacation Packages 2026 from $398

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Your South Carolina Midlands Vacation

Whether you're heading to South Carolina Midlands for its rich history, spectacular views or something else entirely, this destination is one you won't forget in a hurry. Create your ultimate break with one of our South Carolina Midlands vacation packages. With so much to see and do on a trip to South Carolina Midlands, it can be difficult to know where to start. Kick off your travels in Columbia at Riverbanks Zoo and Garden and Williams Brice Stadium — two popular attractions here. Another city worthy of a spot on your itinerary is Florence. Don't miss Magnolia Mall and Mcleod Regional Medical Center. Expedia has flights, hotels, car rentals and more to help you create your very own customized South Carolina Midlands vacation today.

The Latest South Carolina Midlands vacation packages

Price found within the past 48 hours. Click for updated prices.

Westgate Myrtle Beach Oceanfront Resort

Save 100% on your flight

$398

per person

Nov 7 - Nov 11

found 15 hours ago

Roundtrip non-stop flight included

Boston (BOS) to Myrtle Beach (MYR)

8.6/10 Excellent! (1,299 reviews)

Charlotte Marriott City Center

Uptown Charlotte

Save 100% on your flight

$1,088

per person

Sep 24 - Sep 30

found 1 day ago

Roundtrip flight included

Boston (BOS) to Charlotte (CLT)

8.8/10 Excellent! (1,002 reviews)

Marina Inn Grande Dunes Condos & Suites

$817

per person

Sep 25 - Sep 29

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Myrtle Beach (MYR)

9.4/10 Exceptional! (192 reviews)

Our stay was brief but service was excellent for our short stay.

Reviewed on Aug 24, 2026

Marina Inn At Grande Dunes

$795

per person

Sep 25 - Sep 29

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Myrtle Beach (MYR)

9.4/10 Exceptional! (1,790 reviews)

I always stay here when I come to Myrtle Beach. The room was nice except this time the shower handle fell off and the plastic strip on shower door fell also. I also noticed the shower was not as clean as it could have been.

Reviewed on Aug 24, 2026

The Westin Charlotte

Uptown Charlotte

$728

per person

Nov 5 - Nov 8

found 1 day ago

Roundtrip flight included

Boston (BOS) to Charlotte (CLT)

9.2/10 Wonderful! (1,019 reviews)

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Where to stay in South Carolina Midlands

Find the best South Carolina Midlands areas and neighborhoods for the activities you enjoy most. Learn more about South Carolina Midlands

A large church with a tall bell tower and a cross on top.

Downtown Columbia

3 out of top 10 points of interest in this area

A magnet for visitors to the southeast, this compact city is a favorite for its charm, cuisine, historic neighborhoods, world-class museums and pretty green spaces.

A cityscape with a mix of modern and historic buildings, a large parking lot, and a clear sky.

The Vista

The Vista is popular for its abundant dining options, and if you're looking for more to see and do, you might think about a trip to Colonial Life Arena or Koger Center for the Arts.

A cityscape with prominent government buildings, including a large white structure with columns and a dome, surrounded by smaller buildings and a mix of green spaces and urban development.

Rosewood

If you're looking for some top things to see and do in Rosewood and surrounding area, you can visit South Carolina State Fairgrounds and Williams Brice Stadium.

A river surrounded by dense green foliage and white flowers.

Tega Cay

Discover a picturesque peninsula with a 27-hole golf course, croquet court, lighted tennis and pickleball courts, walking trails, and 13 city-owned parks. Enjoy the hilly, densely forested terrain and abundant wildlife.

A cityscape with a large stadium, dense urban buildings, and surrounding greenery.

Eau Claire

Travelers like the parks in Eau Claire, and Three Rivers Greenway is a top attraction you might want to visit.

Stay near popular South Carolina Midlands attractions

A roller coaster with multiple tracks and loops.

Carowinds Theme Park

8.8/10 (962 reviews)

Choose from 13 roller coasters, chase your friends in a bumper car, enjoy the water slides and beaches of Boomerang Bay, and walk with dinosaurs.

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A cityscape at dusk with illuminated buildings, a prominent dome structure, and a well-lit street.

University of South Carolina

9.0/10 (2,467 reviews)

Walk around the campus of University of South Carolina, a top university in Columbia. Experience the area's acclaimed theater scene or attend a sporting event.

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A pond with flamingos standing in the water.

Riverbanks Zoo and Garden

8.8/10 (1,195 reviews)

Why not meet the animals who call Riverbanks Zoo and Garden home during your trip to Columbia? You can attend a sporting event while in the area.

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Williams Brice Stadium

8.8/10 (938 reviews)

Catch an event at Williams Brice Stadium during your trip to Columbia. You can attend a sporting event while in the area.

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Colonial Life Arena

8.8/10 (1,029 reviews)

Catch an event at Colonial Life Arena during your trip to Columbia. Experience the area's acclaimed theater scene or attend a sporting event.

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Columbia Metropolitan Convention Center

8.4/10 (594 reviews)

Learn about the events happening at Columbia Metropolitan Convention Center during your trip to Columbia. Experience the area's acclaimed theater scene or attend a sporting event.

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Darlington Raceway

8.2/10 (151 reviews)

Catch an event at Darlington Raceway during your trip to Darlington. While in this trendy area, you can savor the top-notch restaurants.

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South Carolina Midlands Hotel Deals

Hilton Garden Inn Columbia/Harbison

434 Columbiana Dr Columbia SC

Fully refundableReserve now, pay when you stay

$92 nightly

$103 total

Sep 13 - Sep 14

Total with taxes and fees

9/10 Wonderful! (2,278 reviews)

"good"

Reviewed on Aug 24, 2026

Quality Inn & Suites Florence Civic Center

150 Dunbarton Dr Florence SC

Fully refundableReserve now, pay when you stay

$88 nightly

$99 total

Aug 25 - Aug 26

Total with taxes and fees

8.4/10 Very Good! (339 reviews)

"I had a great stay. Everything was perfect and staff was great."

Reviewed on Aug 24, 2026

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

7333 Garners Ferry Rd Columbia SC

Fully refundableReserve now, pay when you stay

$102 nightly

$114 total

Aug 30 - Aug 31

Total with taxes and fees

See all 3,343 properties in South Carolina Midlands

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.